SATB2 is a transcriptional regulator involved in osteoblastic and neuronal differentiation and is a sensitive and specific marker of colorectal epithelium. This study aimed to evaluate the expression of SATB2 in NNs from various primary sites and its utility as a marker in determining the site of origin of these neoplasms.

Expression of SATB2 (FLJ21474, KIAA1034) in cancer tissue. The cancer tissue page shows antibody staining of the protein in 20 different cancers.

SATB2 is a transcriptional regulator involved in osteoblastic and neuronal differentiation and is a sensitive and specific marker of colorectal epithelium. This study aimed to evaluate the expression of SATB2 in NNs from various primary sites and its utility as a marker in determining the site of origin of these neoplasms. SATB2 is a biomarker for colorectal cancer, 85% of all CRC patients are positive for SATB2 and other cancer types rarely display SATB2 expression SATB2 in combination with cytokeratin 20 identifies over 95% of all colorectal carcinomas ( Am J Surg Pathol 2011;35:937 ) Special AT-rich binding protein 2 (SATB2) immunohistochemistry (IHC) has high sensitivity and specificity for colorectal adenocarcinoma (CRC), but data on its expression in specific subsets of pulmonary, gastric, small bowel, and pancreatobiliary adenocarcinomas (ADCAs) are relatively limited or discordant. The differential diagnosis of glandular lesions of the bladder/urinary tract can be challenging because of significant morphologic and immunohistochemical overlap between primary lesions and metastasis/direct extension from adjacent organs. Special AT-rich sequence-binding protein 2 (SATB2), encoded on chromosome 2q32-33, is a recently described DNA-binding protein involved in osteoblast lineage commitment and expressed in colorectal and appendiceal neoplasms.

Satb2 immunohistochemistry

Immunogen… SATB2 and TLE1 Expression in BCOR-CCNB3 (Ewing-like) Sarcoma, Mimicking Small Cell Osteosarcoma and Poorly Differentiated Synovial Sarcoma. Development of an Automated PD-L1 Immunohistochemistry (IHC) Assay for Non–Small Cell Lung Cancer; Back to Top. Never Miss an Issue. SATB2 (P281) Teoo o Ab Special AT-rich sequence binding-protein 2 ( SATB2) I. Introduction It is estimated that 3% to 5% of all cancers present as a metastasis from an unknown primary site, also known as cancer of unknown primary (CUP). 1 For these CUP cases, immunohistochemistry (IHC) may be utilized to narrow the No cystoscopies were attempted. PAX8, GATA3, and TTF1 were negative in all cases.

Cited in 164 publication(s). Independently reviewed in 15 review(s).

Knockout Tested Rabbit recombinant monoclonal SATB2 antibody [EPNCIR130B ]. Validated in WB, IHC and tested in Human.

SATB2 is a sensitive marker for colorectal adenocarcinomas. No study has investigated its diagnostic utility in metastatic Krukenberg tumors (MKTs) of the ovary.Here we performed immunohistochemical staining SATB2 in 70 MKTs of various origins (stomach 27, colorectum 13, appendix 20 including 19 metastatic adenocarcinomas ex goblet cell carcinoids [AdexGCC] and 1 conventional poorly SATB2 Positive Control Slides, Product No. 384S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections). Physical form Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide. Preparation Note Antibody information for antibodies HPA001042, HPA029543, CAB023669, CAB062562, CAB067751, CAB068229, CAB068230 and CAB068231 used in analysis of ENSG00000119042 / SATB2 … 2019-11-26 2017-09-01 SATB2 immunohistochemistry was scored for extent (%) and intensity (0–3+), with an H‐score being calculated.

Expression of SATB2 (FLJ21474, KIAA1034) in cancer tissue. The cancer tissue page shows antibody staining of the protein in 20 different cancers.

SATB2 in combination with CK20 and Cadherin 17 could identify almost all colorectal carcinomas, including poorly differentiated colorectal carcinomas. Immunohistochemistry was used to analyze the extent of SATB2 expression in tissue microarrays with tumors from 9 independent cohorts of patients with primary and metastatic CRCs (n=1882). Mouse monoclonal SATB2 antibody [SATBA4B10] - C-terminal. Validated in WB, IP, ICC and tested in Mouse, Human. Cited in 164 publication(s). Independently reviewed in 15 review(s).

2019-06-25 · SATB2 expression was also detected in 15% of ovarian endometrioid carcinoma but less than 5% of other ovarian These cases were all scored for SATB2 and PAX8. Immunohistochemistry and scoring. Immunohistochemistry analysis in human rectum and skeletal muscle tissues using AMAb90635 antibody. Corresponding SATB2 RNA-seq data are presented for the same tissues. SATB2 and TLE1 Expression in BCOR-CCNB3 (Ewing-like) Sarcoma, Mimicking Small Cell Osteosarcoma and Poorly Differentiated Synovial Sarcoma Creytens, David MD, PhD *,† Author Information Mouse monoclonal SATB2 antibody [SATBA4B10] - C-terminal.
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Tested Reactivity: Human, Rat, Mouse. 100% Guaranteed. Immunohistochemical results are summarised in tables 2⇓–4. Examples of SATB2 immunostaining are shown in figure 1.

Several publications have documented SATB2 expression in the epithelium of the lower gastrointestinal tract (appendix, colon, and rectum). SATB2 is a new immunohistochemical marker with a few studies showing that it is specifically expressed in a large majority of colorectal adenocarcinomas. We assessed SATB2 along with CDX2 in patient material with metastasis in order to determine whether the primary site could be identified as ‘colon‐rectum’. The Pathology Atlas contains mRNA and protein expression data from 17 different forms of human cancer, as well as correlation analysis of mRNA expression and patient survival.
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SATB2 was expressed by 96% of rectosigmoid NETs, 79% of appendiceal NETs, and only 7% of other well-differentiated neoplasms (P < 0.0001). Se hela listan på academic.oup.com SATB2 was expressed in 2.0% of OMN, 77.8% of AMN, and 49.2% of CRC cases. CK7 was positive in 78.0% of OMN, 33.3% of AMN, and 9.5% of CRC cases.